Slc5a8 sodiumcoupled monocarboxylate transporter 1 homo. It is responsible for the transport of a broad range of monocarboxylate solutes, such as circulating lactate, pyruvate, and acetoacetic acid that can serve as an alternative energy source oldendorf, 1973. Toshihiko iwanaga 1, ayuko kishimoto 1 1 laboratory of histology and cytology, graduate school of medicine, hokkaido university released on jstage 20151030 received 20150715 accepted 20150801. The monocarboxylate transporters mct1 and the sodiumcoupled mct. A novel nutrient sensing mechanism underlies substrateinduced regulation of. Compared with the con diet, the ems intake upregulated jejunal expression of sodium coupled monocarboxylate transporter smct, glucagonlike peptide 1 glp1 and gastric inhibitory polypeptide gip p0.
Kanner and elia zomot department of biochemistry, hebrew university, hadassah medical school, post of. It is a proton coupled monocarboxylate transporter. The transporter responsible for lactate reabsorption in the kidney has now been cloned. Cellular distributions of monocarboxylate transporters. You could also do it yourself at any point in time. Currently, fourteen members of this transporter family have been identified by sequence homology, of which only the first four members mct1 mct4 have been shown to mediate the protonlinked transport of monocarboxylates. Ganapathy v, thangaraju m et al 2008 sodiumcoupled monocarboxylate transporters in normal tissues and in cancer. All structured data from the main, property, lexeme, and entityschema namespaces is available under the creative commons cc0 license. Compared with the con diet, the ems intake upregulated jejunal expression of sodiumcoupled monocarboxylate transporter smct, glucagonlike peptide1 glp1 and gastric inhibitory polypeptide gip p0. These monocarboxylates are transfered through the plasma membrane by proton coupled monocarboxylate transporters mcts and sodium coupled mcts smcts. Sodium iodide symporter, sodium dependent multivitamin transporter and sodium coupled monocarboxylate transporters c unless otherwise stated all data on this page refer to the human proteins.
Slc5a12 sodiumcoupled monocarboxylate transporter 2. Sodiumglucose transport proteins is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Recently, the authors identified two sodium coupled monocarboxylate transporters smcts, smct1 a highaffinity transporter and smct2 a lowaffinity transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and betadhydroxybutyrate. Recently, the authors identified two sodiumcoupled monocarboxylate transporters smcts, smct1 a highaffinity transporter and smct2 a lowaffinity transporter. Sodiumcoupled monocarboxylate transporter 1 wikipedia. In the present study, the authors asked whether smct1. Expression of the sodiumcoupled monocarboxylate transporters. Discovery and characterization of novel inhibitors of the. Another transporter family involved in the transport of endogenous monocarboxylates is the sodium coupled mcts smcts. Martin pm 1, dun y, mysona b, ananth s, roon p, smith sb, ganapathy v. Slc5a8 sodiumcoupled monocarboxylate transporter 1 mus.
Mar 19, 2014 dna extraction and ion torrent v6 16s rrna sequencing. Figure 1 key metabolic pathways requiring monocarboxylate transport across the. Sodiumcoupled electrogenic transport of pyroglutamate 5 oxoproline via slc5a8, a monocarboxylate transporter article in biochimica et biophysica acta 17986. Slc5a8 and slc5a12 are sodium coupled monocarboxylate transporters smcts, the former being a highaffinity type and the latter a lowaffinity type. A guide to the metabolic pathways and function of metabolites. They are expressed in the gastrointestinal tract, kidney, thyroid, brain, and retina. Tims s, torrents d, ugarte e, zoetendal eg, wang j, guarner f, pedersen o. Sodiumcoupled monocarboxylate transporters in normal. Hydroxybutyric acid ghb, a drug of abuse, is a substrate of monocarboxylate transporters mcts.
The current knowledge of the normal biochemistry of compounds that give rise to resonances in human brain proton magnetic resonance spectra measureable at readily available field strengths i. Sodium iodide symporter, sodiumdependent multivitamin transporter and sodiumcoupled monocarboxylate transporters c unless otherwise stated all data on this page refer to the human proteins. Sodiumglucose transport proteins harvard catalyst profiles. Slc5a8 sodiumcoupled monocarboxylate transporter 1 function.
Sodiumcoupled monocarboxylate transporters in normal tissues. Sodium glucose transport proteins is a descriptor in the national library of medicines controlled vocabulary thesaurus, mesh medical subject headings. Primary structure and functional characteristics of a. A novel nutrient sensing mechanism underlies substrateinduced regulation of monocarboxylate transporter1. Cloning and functional identification of slc5a12 as a sodiumcoupled. Monocarboxylate transporter 1 is a protein that in humans is encoded by the slc16a1 gene also known as mct1. Slc5a8 sodiumcoupled monocarboxylate transporter 1. Evidence for greater production of colonic shortchain fatty. Monocarboxylic acid transport university of bristol. Monocarboxylate transporter an overview sciencedirect topics. Slc5a8 gene genecards sc5a8 protein sc5a8 antibody. Monocarboxylate transporter 1 mct1 is expressed on the luminal membrane of bcecs gerhart et al.
Sodiumcoupled monocarboxylate transporter is a target of. Slc5a8 is expressed in kidney, thyroid gland, neurons, and intestinal tract and exhibits substrate specificity similar to that of the protondependent mct slc16a family. Sodium coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the slc5a8 gene. Ectopic expression of the transporter in transporterdeficient colon.
Apr 02, 2008 slc5a8 and slc5a12 are sodium coupled monocarboxylate transporters smcts, the former being a highaffinity type and the latter a lowaffinity type. The pdf version of the atlas of genetics and cytogenetics in oncology and haematology is a reissue of the original articles published in collaboration with the. Sodiumcoupled neurotransmitter transporters baruch i. Expression of mct1, mct2, mct4, gp70 and cd147 in mammalian. It is responsible for the transport of a broad range of monocarboxylate solutes, such as circulating lactate, pyruvate, and acetoacetic acid that can serve as an alternative energy source oldendorf. Slc5a8 is localized to the apical membrane of epithelial cells lining the intestinal tract. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and. Discovery and characterization of novel inhibitors of the sodiumcoupled citrate transporter nact or slca5 skip to main content thank you for visiting. Evidence for greater production of colonic shortchain fatty acids in.
Monocarboxylate transporter an overview sciencedirect. Expression of the sodium coupled monocarboxylate transporters smct1 slc5a8 and smct2 slc5a12 in retina. Role of monocarboxylate transporters in drug delivery to. Dna extraction and ion torrent v6 16s rrna sequencing. Slc5a8 and slc5a12 are sodiumcoupled monocarboxylate transporters.
The monocarboxylate transporters mct1 and the sodiumcoupled mct smct were suggested to facilitate the transport of scfa faecal acetate mmolkg wet wt p 0. Gene information is provided for human hs, mouse mm and rat rn. Shortchain fatty acids acetate, propionate, and butyrate, produced by bacterial fermentation, supply most of the energy substrates in ruminants such as the cow and sheep. The slc5a8 gene encodes na monocarboxylate transporter 1, which is epigenetically inactivated in various tumour types. Evidence for greater production of colonic shortchain. Expression of smct1 and smct2 has been studied in several tissues. Sodiumcoupled monocarboxylate transporter 1 is a protein that in humans is encoded by the slc5a8 gene. Pdf sodiumcoupled monocarboxylate transporters in normal. Dna extraction and ion torrent v6 16s rrna sequencing were performed. Cd147 is tightly associated with lactate transporters mct1 and. Slc5a8 is localized to the apical membrane of epithelial cells lining the. Discovery and characterization of novel inhibitors of the sodium coupled citrate transporter nact or slca5 skip to main content thank you for visiting. Sodiumglucose cotransporters, structure and function.
Sodium iodide symporter, sodiumdependent multivitamin. Qualitative modelling of the interplay of inflammatory status and. Brief history of two neurotransmitter transporter families 1655 1. The active transport of krebs cycle intermediates, such as succinate and citrate, is mediated by a specific sodiumcoupled transporter found on the apical membrane in epithelial cells of the kidney proximal tubule 1, 2. Role of monocarboxylate transporters in drug delivery to the.
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